学校:首都师范大学
专业:理学->生物学->生物化学与分子生物学
年级:2019
招生人数:5
招生状态:正在招生中
1.招生类型：2019年硕士调剂生，科研型
2.招收学校(单位)名称：首都师范大学,生命科学学院
3.学制以及何种专业：三年制硕士，生物化学和细胞生物学方向
4.学校或单位地点：北京市海淀区
5.导师(课题组)介绍：李夏璐博士1995年毕业于复旦大学生物化学系，获学士学位；2000年从中国科学院上海生物化学研究所获博士学位；同年11月赴美工作，在哥伦比亚大学生物系从事5年博士后研究，2006年回国在北京生命科学研究所建立独立研究团队，2013年起受聘为首都师范大学生命科学学院特聘教授。李博士长期开展生物化学和细胞生物学研究，相应研究工作已在Cell、Genes & Development和PNAS等国际一流学术期刊上发表，多项研究成果被Faculty 1000 of Biology推荐。曾主持完成国家高技术研究发展计划（863）和国家重点基础研究发展计划（973）课题各一项。目前在研国家自然科学基金委面上项目和国家重大研究计划（973课题负责人）资助各一项。实验室主要研究兴趣在于运用遗传学，分子生物学，生物化学和生物信息学等方法，理解哺乳动物细胞是如何应对在生长和增殖过程中必然会面对的RNA转录、DNA复制和基因组稳定性维护三者间的冲突；并探索这一冲突形成后可能产生的病理后果。希望实验室研究工作有助于加深对于肿瘤等重大疾病发病机理的理解，从而为癌症的诊断、治疗和药物的开发提供新的理论基础。
发表文章(*责任作者)
1. Bing Liang, Peng Peng, She Chen, Lin Li, Meijun Zhang, Dongyan Cao, Jiaxin Yang, Haixia Li, Ting Gui, Xialu Li* and Keng Shen*, Characterization and proteomic analysis of ovarian cancer-derived exosomes, Journal of Proteomics, vol.80, p171-182, 2013
2. Wenxing Jin, Zhaoyang Niu, Dan Xu and Xialu Li*, RBM5 promotes exon 4 skipping of AID pre-mRNA by competing with the binding of U2AF65 to the polypyrimidine tract, FEBS Lett, vol. 586,p3852-3857, 2012.
3. Zhaoyang Niu, Wenxing Jin, Libo Zhang, Xialu Li*, Tumor suppressor RBM5 directly interacts with the DExD/H-box protein DHX15 and stimulates its helicase activity, FEBS Lett, vol. 586, p977-983, 2012.
4. Yuichi Kanehiro, Kagefumi Todo, Misaki Negishi, Junji Fukuoka, Wenjian Gan, Takuya Hikasa, Yoshiaki Kaga, Masayuki Takemoto, Masaki Magari, Xialu Li, James L.Manley, Hitoshi Ohmori, Naoki Kanayama, Activation-induced cytidine deaminase (AID)-dependent somatic hypermutation requires a splice isoform of the serine/arginine-rich (SR) protein SRSF1, Proc Natl Acad Sci USA, vol.109, pp1216-1221, 2012 (Selected by faculty 1000 of biology)
5. Wenjian Gan, Zhishuang Guan, Jie Liu, Ting Gui, Keng Shen, James.L. Manley, Xialu Li*, R-loop-mediated genomic instability is caused by impairment of replication fork progression, Genes & Development, vol. 25, pp2041-2056, 2011 (Selected by faculty 1000 of biology)
6. Xialu Li and James L. Manley, 2009, The Role of Alternative Splicing During the Cell Cycle and Programmed Cell Death. In Ralph A. Bradshaw and Edward A. Dennis, editors: Handbook of Cell Signaling 2nd edition, Oxford:Academic Press, pp. 2329-2334. (invited book chapter)
7. Xialu Li*, Tianhui Niu., and James L Manley. 2007. The RNA binding protein RNPS1 alleviates ASF/SF2 depletion-induced genomic instability. RNA 13(12): 2108-2115
8. Xialu Li and James L Manley, 2006, Co-transcriptional processes and their influence on genome stability. Genes & Development, 2006; 20(14):1838-1847.
9. Xialu Li and James L Manley. 2006. Alternative Splicing and Control of Apoptotic DNA Fragmentation. Cell Cycle 5(12).1286-1288
10. Xialu Li and James L. Manley, 2005, New talents for an old acquaintance: the SR protein splicing factor ASF/SF2 functions in the maintenance of genome stability. Cell cycle, 4(12): 1706-1708.
11. Xialu Li, Jin Wang and James L Manley, 2005, Loss of splicing factor ASF/SF2 induces G2 cell-cycle arrest and apoptosis, but inhibits internucleosomal DNA fragmentation, Genes & Development, 19(22):2705-2714.
12. Xialu Li and James L Manley, 2005, Inactivation of the SR protein splicing factor ASF/SF2 results in genomic instability. Cell, 122 (3), p365-378. (Selected by faculty 1000 of biology)
13. Boliang Li, Xialu Li et al., 1999, Human acyl-CoA:Cholesterol acyltransferase-1 (ACAT-1) gene organization and evidence that the 4.3-kilobase ACAT-1 mRNA is produced from two different chromosomes., J Biol Chem, 274 (16): p11060-11071
