个人简介
办公电话:022-60602099
电子邮件:hehongpeng@tust.edu.cn
通讯地址:天津经济技术开发区第十三大街29号天津科技大学生物工程学院
研究方向: 主要致力于利用分子生物学和表观遗传学的方法研究基因的表达调控及其与疾病的关系。同时,研究各种小分子药
招生专业
院系名称 | 专业大类 | 一级学科 | 专业代码/专业名称 | 学位类型 | 招生类型 | 类型 |
---|---|---|---|---|---|---|
生物工程学院 | 理学 | 药学 | 078001 药物化学 | 学术型 | 硕士 | 全日制 |
代表性论文
1. Hongpeng HE, Fa-Xing YU, Chi SUN, Yan LUO. CBP/p300 and SIRT1 are involved in transcriptional regulation of S-phase specific histone genes. PLoS One. 2011; 6(7):e22088. Epub 2011 Jul 15.
2. Hongpeng HE* and Yan LUO*. Brg1 regulates the transcription of human papillomavirus type 18 E6 and E7 genes. Cell Cycle. 2012 Feb 1;11(3).
3. Hongpeng HE, Mei-Chin LEE, Li-Ling ZHENG, Lei ZHENG, Yan LUO*. Integration of the Metabolic/Redox State, Histone Gene Switching, DNA Replication and S-phase Progression by Moonlighting Metabolic Enzymes. Biosci Rep. 2013 33(2),
4. He Hongpeng, Liu X, Wang D, Wang Y, Liu L, Zhou H, Luo X, Wang N, Ji B, Luo Y, Zhang T. SAHA inhibits the transcription initiation of HPV18 E6/E7 genes in HeLa cervical cancer cells. Gene. 2014 Oct 6. v553 (2014) p98–104.
5. He Hongpeng, Wang D, Yao H, Wei Z, Lai Y, Hu J, Liu X, Wang Y, Zhou H, Wang N, Luo XG, Zhang TC. Transcriptional factors p300 and MRTF-A synergistically enhance the expression of migration-related genes in MCF-7 breast cancer cells. Biochem Biophys Res Commun. 2015 Oct 19.v467:813-820.
6. Xing-Hua Liao(#),Li Zheng(#),Hong-Peng He(#),De-Liang Zheng,Zhao-Qiang Wei,Nan Wang,Jian Dong,Wen-Jian Ma,Tong-Cun Zhang,STAT3 regulated ATR via microRNA-383 to control DNA damage to affect apoptosis in A431 cells,Cellular Signalling,2015,27(11):2285-2295.
7. Tin Fan CHAI, YC LECK, Hongpeng HE, Fa-Xing YU, Yan LUO*, Thilo HAGEN*. Hypoxia-inducible factor independent down-regulation of thioredoxin-interacting protein in hypoxia. FEBS Lett. 585(3):492-8. 2011。
8. Fa-Xing YU, Tin Fan CHAI, Hongpeng HE, Thilo HAGEN, Yan LUO*. Thioredoxin-interacting protein (Txnip) gene expression: sensing oxidative phosphorylation status and glycolytic rate. J Biol Chem. 285(33):25822-30. 2010。
9. Tin Fan CHAI, SY HONG, Hongpeng HE, Li-Ling ZHENG, Thilo HAGEN, Yan LUO, Fa-Xing YU*. A potential mechanism of metformin-mediated regulation of glucose homeostasis: inhibition of Thioredoxin-interacting protein (Txnip) gene expression. Cell Signal. 24(8):1700-5. 2012。
10. Li Man, Wang Nan, Gong Hui-Qin, Li Wei-Zong, Liao Xing-Hua, Yang Xiao-Long, He Hong-Peng, Cao Dong-Sun, Zhang Tong-Cun. Ca2? signal-induced cardiomyocyte hypertrophy through activation of myocardin. Gene. 2015 Feb 15;557(1):43-51.
11. Jian Ruo-Lei; Mao Li-Bin; Xu Yao; Li Xiao-Fan; Wang Feng-Po; Luo Xue-Gang; Zhou Hao; He Hong-Peng; Wang Nan; Zhang Tong-Cun. Generation of insulin-producing cells from C3H10T1/2 mesenchymal progenitor cells. Gene. 2015 Feb 25. [Epub ahead of print]
12. Zhang, Rui(#),Wang, Nan,Zhang, Man,Zhang, Li-Nan,Guo, Zhi-Xia,Luo, Xue-Gang,Zhou, Hao,He, Hong-Peng,Zhang, Tong-Cun,Rho/MRTF-A-Induced Integrin Expression Regulates Angiogenesis in Differentiated Multipotent Mesenchymal Stem Cells.,Stem Cells Int,2015,2015:534758-534758。
13. Xiang-Zhu Shu(#),Li-Nan Zhang,Rui Zhang,Cai-Jiao Zhang,Hong-Peng He,Hao Zhou,Nan Wang,Tong-Cun Zhang,Histone acetyltransferase p300 promotes MRTF-A-mediates transactivation of VE-cadherin gene in human umbilical vein endothelial cells,Gene,2015,563(1):17-23。 5.
科研项目
目前主持的课题:
[1] 国家自然基金-青年基金,项目编号31301073,项目名称为“HeLa细胞中人乳头瘤病毒E6/E7基因转录的表观遗传学调控机制”,起止时间:2014年1月至2016年12月。
[2] 天津市科委应用基础与前沿技术研究计划一般项目, 项目编号13JCYBJC38000,项目名称“宫颈癌相关高危型HPV E6/E7病毒癌基因转录调控机制,起止时间:2013年10月至2016年9月。
[3] 天津科技大学人才引进基金,2012。