王相晶
女，1972年生人
博士，教授，博士生导师
联系电话：0451-55190413(O)
传真电话：0451-55190413
电子邮箱：wangxiangjing2008@yahoo.com.cn
教育进修
博士后，浙江大学，2003-2005
博士，哈尔滨工业大学，2000-2003
硕士，东北农业大学，1997-2000
学士，东北农业大学，1989-1992
工作经历
2003年10月评为副教授;2005年12月聘为责任教授，2007年9月评为教授，2008年7月评为博士生导师。
主讲课程
主讲本科生课程《工业微生物》、《生物学专业外语》，主讲硕士研究生课程《微生物育种》课程。
研究方向
Current research interests are about isolating and screening of antibiotic-generating strain, secondary metabolite biosynthesis in microorganisms, gene cloning and expression, enzyme reaction mechanisms, metabolic pathway engineering, and natural product drug discovery and development.
研究课题
1、冰城链霉菌生物合成米尔贝霉素基因簇基因克隆及功能分析，国家自然基金，2010-2012，主持人
2、米尔贝霉素原料药的研制与应用，“十一五”国家支撑重点子项目，2007～2010 主持人
3、删除影响米尔贝霉素生物工艺杂质的高产菌株的选育，黑龙江省教育厅基金，2007～2009 主持人
4、冰城链霉菌生物合成米尔贝霉素基因克隆与功能分析，国家博士后基金一等，2007～2008 主持人
5、生物农药米尔贝霉素高产菌株的选育和发酵工艺的优化，黑龙江省青年专项基金，主持人
6、生物农药多杀菌素生产菌的选育和发酵工艺优化研究，哈尔滨市青年专项基金，主持人
7、γ-氨基丁酸受体筛选模型建立及作用，黑龙江省博士后启动基金，2005～2008 主持人
8、高浓度抗生素废水生物处理新技术与应用研究，国家博士后基金二等，2003～2005 主持人
9、高浓度制药废水生物处理新技术与应用研究，浙江省博士后基金， 2003～2005 主持人
10、高浓度制药废水厌氧生物处理技术研究，校博士启动基金，2005～2008 主持人
获奖成果
黑龙江省科技进步一等奖1项
黑龙江省科技进步二等奖1项
论文著作
发表论文
1. Xiang-Jing Wang, Suo-Lian Guo, Wan-Qian Guo, Wen-Sheng Xiang, Role of nsdA in Negative Regulation of Antibiotic Production and Morphological Differentiation in Streptomyces bingchengensis, J.Antibiotics, 2009, 62(6):329-13(SCI，IF=1.6第一作者)
2. Xiang-Jing Wang, Xiao-Chong Wang, Improvement of milbemycin-producing Streptomyces bingchenggensis by rational screening of ultraviolet- and chemically induced mutants, World Journal of Microbiology and Biotechnology, 2009, 25:1051-1056(SCI，IF=0.8第一作者)
3. Xiang-Jing Wang, Ji-Dong Wang, Wen-Sheng Xiang, Three new milbemycin derivatives from Streptomyces bingchenggensis, Journal of Asian Natural Products Research, 2009, 11 (7), 597–603 (SCI, IF=0.6 第一作者)
4. Wen-Sheng Xiang, Ji-Dong Wang, Xiang-Jing Wang, A novel macrolide compound from the Streptomyces bingchenggensis, Fermentation, Isolation, Structure Elucidation and Biological Properties, J.Antibiotics, 2009, 62(4):229-31(SCI, IF=1.6,责任作者)
5. Wen-Sheng Xiang, Ji-Dong Wang, Xiang-Jing Wang, Ji Zhang, Bingchamides A and B, two novel cyclic pentapeptides from the Streptomyces bingchenggensis: fermentation, isolation, structure elucidation and biological properties, 2009,62( SCI, IF=1.6，责任作者)
6. Wen-Sheng Xiang, Ji-Dong Wang, Xiang-Jing Wang, New Seco-milbemycins from Streptomyces bingchenggensis: Fermentation, Isolation and Structure Elucidation，J.Antibiotics, 2008, 61 (1): 27-32(SCI，IF=1.6,责任作者)
7.Wen-Sheng Xiang, Ji-Dong Wang, Xiang-Jing Wang, Two new components from Gnetum pendulum，J. of Asian Natural Products Research，2008, 10: 1-5(SCI，IF=0.6,责任作者)
8. Wen-Sheng Xiang, Ji-Dong Wang, Xiang-Jing Wang, Two new milbemycins from Streptomyces bingchenggensis Fermentation, Isolation, Structure Elucidation and Biological properties, J.Antibiotics, 2007, 60 (6):351-356(SCI，IF=1.6,责任作者)
9.Wen-Sheng Xiang, Ji-Dong Wang, Xiang-Jing Wang, Further New Milbemycin Antibiotics from Streptomyces bingchenggensis, J.Antibiotics, 2007, 60 (10): 608-613(SCI，IF=1.6,责任作者)
10. Xiangjing Wang, Nanqi Ren, Wensheng Xiang, Influence of Gaseous End-products Inhibition and Nutrient Limitations on the Growth and Hydrogen Production by Hydrogen-producing Fermentative Bacterial B49，International Journal of hydrogen Energy, 2007(32):748-754(SCI， IF=3.2)
11. Wang Xiangjing, Ren Nanqi, The start-up of biohydrogen-producing process by bioaugmentation in the EGSB reactor, High Technology Letters, 2006, 12(3): 328～331(EI)
12. Wang Xiangjing, Ren Nanqi, Xiang Wensheng, Effects of Iron on Hydrogen-producing Capacity, Hydrogenase and NADH-fd Reductase Activities of a Fermentative Hydrogen-producing Bacterial Strain B49, High Technology Letters, 2004,10 (4):69~74(EI)
13. Wang Xiangjing, Ren Nanqi, Xiang Wensheng, Magnesium Improves Hydrogen Production by a Novel Fermentative Hydrogen-producing Bacterial Strain B49，Journal of Institute of Harbin Technology, 2005,12 (2):164~168(EI)
14. Wensheng Xiang, Xiangjing Wang, Expression of a wheat cytochrome P450 monooxygenase cDNA in yeast catalyzes the metabolism of sulfonylurea herbicide. Pest. Biochem. Physio, 2006, 85(1):1-6(SCI， IF=1.4)
15. Xiang Wensheng, Wang Xiangjing, Purification of recombinant wheat cytochrome P450 monooxygenase expressed in yeast and its properties, Protein Expression and Purification, 2006(1):54-59(SCI， IF=1.2)
16. Xiang Wensheng, Wang Xiangjing, Expression of a wheat cytochrome P450 monooxygenase in yeast and its inhibition by glyphosate. Pest Manag. Sci., 2005 Apr;61(4):402-406(SCI， IF=1.5)
17. Nan-Qi Ren, Wan-Qian Guo, Xiang-Jing Wang, Wen-Sheng Xiang. Effects of different pretreatment methods on fermentation types and dominant bacteria for hydrogen production. Int J Hydrogen Energy 2008, 33(16): 4318~4324. (SCI, Ei, IF=2.725)
18. Wan-Qian Guo, Nan-Qi Ren, Xiang-Jing Wang, Wen-Sheng Xiang. Optimization of culture conditions for hydrogen production by Ethanoligenens harbinense B49 using response surface methodology. Bioresource Technology, 2009 Feb;100(3):1192-6(SCI, Ei, IF=3.103)
19. Wan-Qian Guo, Nan-Qi Ren, Xiang-Jing Wang, Wen-Sheng Xiang. Biohydrogen production from ethanol-type fermentation of molasses in an expanded granular sludge bed (EGSB) reactor. Int J Hydrogen Energy 2008, 33(19): 4981~4988. (SCI, Ei, IF=2.725)
20. Wan-Qian Guo, Nan-Qi Ren, Xiang-Jing Wang, Wen-Sheng Xiang. Simultaneous biohydrogen production and starch wastewater treatment in an acidogenic expanded granular sludge bed reactor by mixed culture for long-term operation. Int J Hydrogen Energy, 2008, 10.1016/j.ijhydene.2008.09.039.(SCI, Ei, IF=2.725)
21. 王相晶, 任南琪. 发酵条件对发酵产氢细菌B49产氢的影响，太阳能学报，2005,26 (1):99~103(EI收录)
22. 郭婉茜，任南琪，王相晶. 接种污泥预处理对生物制氢反应器启动的影响.化工学报. 2008, 59(5): 1283~1287. (Ei收录，accession number：082311304125)
23. Ming Wang, Xiao-Hu Yang, Ji-Dong Wang, Xiang-Jing Wang, Zheng-Jie Chen, Wen-Sheng Xiang, New β-Class Milbemycin Compound from Streptomyces Avermitilis NEAU1069: Fermentation, Isolation and Structure Elucidation J.Antibiotics,2009，62(SCI， IF=1.6,)
24. 吕世翔, 郭阳辉, 王亚平, 王相晶, 向文胜, (R)-4-氰基-3-羟基丁酸乙酯的合成新方法, 有机化学(SCI，已接收定稿)
25. Hai Bo Sun, Guo Jun Zheng , Ya Ping Wang, Xiang Jing Wang, Wen Sheng Xiang, Novel synthesis of 2-butyl-5-chloro-3H-imidazole-4-carbaldehyde: A key intermediate of Losartan, Chinese Chemical Letters 20 (2009) 269–270(SCI, IF=0. 7收录)
26. 郭婉茜 ,任南琪 ,曲媛媛 ,王相晶 ,向文胜, 两种类型生物制氢反应器的运行及产氢特性,哈尔滨工业大学学报， 2009, 4(4)：72-76(EI收录)
27. Optimized operational parameters of a pilot scale membrane bioreactor for high-strength organic wastewater treatment. International Biodeterioration and Biodegradation. 第三作者,2005, 56(4): 216~223(SCI 收录)
28. Hydrogen energy recovery from high strength organic wastewater with ethanol type fermentation using acidogenic EGSB reactor. Journal of Institute of Harbin Technology, 第三作者, 2005,12 (6):603~607(EI收录)
29. Wang Xiangjing, Ren Nanqi. Comparative analysis of hydrogen-producing bacteria and its immobilized Cells for Characteristics of hydrogen production, Journal of Institute of Harbin Technology, 2003,10 (4):403~407(EI收录)
30. Ren Nanqi, Wang Xiangjing. Hydrogen Production with High Evolution Rate and High Yield by Immobilized Cells of Hydrogen-Producing Bacterial Strain B49 in a column reactor，High Technology Letters，2002，8(4): 21~25(EI收录)
31. 向文胜，王相晶. 乙氧氟草醚的毛细管气相色谱分析，分析化学，2003, (3) :79(SCI收录
32. 牛奶废水厌氧水解酸化试验研究，哈尔滨工业大学学报，2004,36(3):331~333，337 第四作者(EI收录)
33. Molecular Biological Characterization of a Strain of Biohydrogen-produing Anaerobe in Clostridium Genus，Journal of Institute of Harbin Technology, 2005,12 (2):159~163 第七作者(EI收录)
34. 林明，任南琪，王爱杰，王相晶，混合菌种在发酵法生物产氢中的协同作用，环境科学，2003，24(2)：54~59(EI收录)
著作、教材
(1) “十一五”规划教材《仪器分析》，主编，哈尔滨工业大学出版社
(2) 废物资源化与生物能源 参编 化学工业出版社 2004,3
(3) 厌氧生物技术原理与应用 参编 化学工业出版社 2004,3
